Metastatic breast cancer · Ultra-rare molecular profile

A rare cancer, a real opportunity.

Portrait of Miriam González
Engineer · Communicator

Miriam, 35, has a tumor with two sides that Spanish protocols don't account for. The tests she needs to treat it aren't covered by public healthcare. This site exists to fund them.

Support Miriam

Every euro funds clinical research applied to her case.

See the science

Open the full molecular profile in The science.

Already supported by 970 people · featured in El País

Latest· updated 11 days agoA new scan opens another door

€38,166

raised so far

970

people have contributed

5+

specialists in 3 countries

80%

neuroendocrine differentiation

The story

A diagnosis that fit no protocol.

At 33, Miriam was diagnosed with a metastatic breast cancer so rare it is seen in fewer than 1 in 1,000 cases. The standard treatment isn't enough: it has to be designed around her specific tumor.

Source: SEER population analysis · Transl. Cancer Res., 2023

Get to know Miriam (soon)

In her own words

«My tumor has two sides —the breast side and the neuroendocrine one— and the key is to treat both at once, not just one.»

— Miriam González. May 2026.

Clinical gap

What Spanish protocols don't cover, we cover.

Spanish protocols only account for half of the tumor's biology: they're built for standard HR+ breast cancer, and Miriam's is not.

In practice: hormonal treatment addresses the tumor's side but leaves its component untreated. Confirming and targeting it requires molecular rebiopsy and international expert review — tests public healthcare doesn't cover for such a rare case.

Tap or hover the highlighted words and markers to see what they mean.

What exists vs. what is missing

What the protocols cover

  • Initial diagnosis and routine follow-up
  • Standard hormonal treatment
  • Symptom and toxicity management
  • Reports and clinical documentation

What is missing and not covered

  • Updated multi-omic analysis of the tumor (genomics, transcriptomics, proteomics)
  • Consultation with specialists in uncommon profiles
  • Access to clinical trials designed for her type of case
  • Tests that allow treatment to be adjusted to what the tumor is doing now

Full technical analysis in The science. The essential point: a measurable gap exists between the treatment she receives and the one her biology requires.

Where this is heading

The goal is an N-of-1 trial designed for this tumor's exact biology.

An trial is a clinical trial built for a single patient: treatment is designed around her tumor's actual profile, not an average protocol. That makes it possible to combine drugs to target its two sides at once — the luminal (breast) one and the possible neuroendocrine one.

The advantages of reaching that trial:

  • Treatment is adjusted to the real profile of the tumor, not to a protocol designed for the majority.
  • Drugs suited to each part of the tumor can be applied simultaneously.
  • Every result obtained contributes evidence for other patients with similar profiles.
  • Miriam stops depending on a single protocol that does not answer her case.

In one line, for anyone who wants the detail:

Those with “?” are hypotheses with partial evidence, pending confirmation. Full analysis in The science.

See the full molecular profile

Open clinical documentation. Updated in 2026.

Where the money goes · Radical transparency

The tumor evolves. The strategy has to evolve with it.

The tumor evolves under treatment pressure. New resistance mutations appear (ESR1 D538G, RB1) and new targets emerge (SSTR2+). Without periodic molecular rebiopsy, clinical decisions are made blind.

Every euro is assigned to a concrete line item and documented on the Expenses page.

The money goes to:

  • Molecular tests and diagnostics (rebiopsy, sequencing, panels).
  • Consultations and second opinions with international specialists.
  • Medication and treatments not covered.
  • AI tools, case management and outreach.
See the full breakdown

Three ways to contribute · Pick yours

Not every way to help costs money. Each action counts differently.

01

Level 1 · Share (no cost)

Getting the case in front of whoever can move it forward —in oncology, research or among patients— is often the difference between finding a therapeutic target and not finding one.

Share the site with whoever can move the case forward.

02

Level 2 · Read the science (cognitive commitment)

Understand the full molecular profile, the active biological hypotheses and the compatible clinical trials. Open, reviewed documentation.

Read the molecular profile

No sign-up, no paywall.

03

Level 3 · Fund (financial commitment)

Every euro funds research applied to the case: deep sequencing, molecular rebiopsy, international second opinions, N-of-1 trial.

Support Miriam

Secure payment. Receipt available. 100% to Miriam's case.

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Every euro brings the next priority molecular analysis closer.